HRM may stand for:
- His or Her Royal Majesty, a style used by King-Emperors and their consorts as heads of imperial dynasties that were simultaneously royal
- Halifax Regional Municipality, the capital of the province of Nova Scotia, Canada
- Human resource management, the academic theory and business practice of managing a workforce
- Heart rate monitor, a device that allows a user to measure his or her heart rate in real time
- High reactivity metakaolin, a reactive aluminosilicate pozzolan that reacts with slaked lime to form a strong slow-hardening cement
- Ḥ-R-M, a triconsonantal Arabic root
- Human Race Machine, a computerized console created by Nancy Burson
- Croatian Navy, (Croatian: Hrvatska ratna mornarica) a branch of the Croatian Armed Forces
- High Resolution Melt, a technique for the detection of mutations, polymorphisms and epigenetic differences in double stranded DNA samples
- High resolution manometry, a gastrointestinal motility diagnostic system that measures intraluminal pressure activity.