Hlhr

Identifiers Symbols LHCGR; HHG; LCGR; LGR2; LH/CG-R; LH/CGR; LHR; LHRHR; LSH-R; ULG5 External IDs OMIM: 152790 MGI: 96783 HomoloGene: 37276 IUPHAR: LH receptor ChEMBL: 1854 GeneCards: LHCGR Gene

Gene Ontology
Molecular function	• luteinizing hormone receptor activity • G-protein coupled peptide receptor activity • peptide hormone binding • choriogonadotropin hormone receptor activity • choriogonadotropin hormone binding • protein homodimerization activity • ATPase binding
Cellular component	• extracellular space • nucleus • lysosome • endosome • endoplasmic reticulum • plasma membrane • integral to plasma membrane • intrinsic to external side of plasma membrane • receptor complex
Biological process	• ovarian follicle development • protein targeting to lysosome • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • activation of adenylate cyclase activity • phospholipase C-activating G-protein coupled receptor signaling pathway • spermatogenesis • central nervous system development • male gonad development • hormone-mediated signaling pathway • male genitalia development • positive regulation of inositol trisphosphate biosynthetic process • response to drug • positive regulation of cAMP-mediated signaling • development of secondary male sexual characteristics • positive regulation of hormone biosynthetic process • arachidonic acid secretion • positive regulation of calcium-mediated signaling • positive regulation of release of sequestered calcium ion into cytosol • uterus development • cellular response to gonadotropin stimulus • seminiferous tubule development • regulation of steroid hormone biosynthetic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3973 16867 Ensembl ENSG00000138039 ENSMUSG00000024107 UniProt P22888 P30730 RefSeq (mRNA) NM_000233.3 NM_013582.2 RefSeq (protein) NP_000224.2 NP_038610.1 Location (UCSC) Chr 2:
48.86 – 48.98 Mb Chr 17:
88.74 – 88.79 Mb PubMed search

The luteinizing hormone/choriogonadotropin receptor (LHCGR), also lutropin/choriogonadotropin receptor (LCGR) or luteinizing hormone receptor (LHR) is a transmembrane receptor found predominantly in the ovary and testis, but also many extragonadal organs such as the uterus and breasts. The receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning during reproduction.