Hlhr
Gene Ontology | |
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Molecular function | • luteinizing hormone receptor activity • G-protein coupled peptide receptor activity • peptide hormone binding • choriogonadotropin hormone receptor activity • choriogonadotropin hormone binding • protein homodimerization activity • ATPase binding |
Cellular component | • extracellular space • nucleus • lysosome • endosome • endoplasmic reticulum • plasma membrane • integral to plasma membrane • intrinsic to external side of plasma membrane • receptor complex |
Biological process | • ovarian follicle development • protein targeting to lysosome • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • activation of adenylate cyclase activity • phospholipase C-activating G-protein coupled receptor signaling pathway • spermatogenesis • central nervous system development • male gonad development • hormone-mediated signaling pathway • male genitalia development • positive regulation of inositol trisphosphate biosynthetic process • response to drug • positive regulation of cAMP-mediated signaling • development of secondary male sexual characteristics • positive regulation of hormone biosynthetic process • arachidonic acid secretion • positive regulation of calcium-mediated signaling • positive regulation of release of sequestered calcium ion into cytosol • uterus development • cellular response to gonadotropin stimulus • seminiferous tubule development • regulation of steroid hormone biosynthetic process |
Sources: Amigo / QuickGO |
48.86 – 48.98 Mb
88.74 – 88.79 Mb
The luteinizing hormone/choriogonadotropin receptor (LHCGR), also lutropin/choriogonadotropin receptor (LCGR) or luteinizing hormone receptor (LHR) is a transmembrane receptor found predominantly in the ovary and testis, but also many extragonadal organs such as the uterus and breasts. The receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning during reproduction.
Read more about Hlhr: LHCGR Gene, Receptor Structure, Ligand Binding and Signal Transduction, LHCGR Abnormalities, History, Interactions