Genetic Linkage
| DR17 Haplotypes | ||||
| Serotypes | DRA | DRB1 | DRB3 | |
|---|---|---|---|---|
| DR17 | *0101 | *0301 | 0101 | |
| *0101 | *0301 | 0201 | ||
| Serotypes | DQA1 | DQB1 | DRB1 | |
| DR17(3)-DQ2(2.5) | *0501 | *0201 | *0301 | |
| Serotypes | HLA-A | HLA C | HLA B | DRB1 |
| A1-Cw7-B8-DR17(3) | *0101 | *0701 | *0801 | *0301 |
| A2-Cw7-B8-DR17(3) | *0201 | *0701 | *0801 | *0301 |
| A30-Cw5-B18-DR17(3) | *3002 | *0501 | *1801 | *0301 |
HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles. DRB1*0301 is frequently within by the "Super-B8" or ancestral HLA haplotype:
A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201
This haplotype is known as "Super B8", "European ancestral haplotype", or "AH8.1"
Read more about this topic: HLA-DR17
Famous quotes containing the word genetic:
“Nature, we are starting to realize, is every bit as important as nurture. Genetic influences, brain chemistry, and neurological development contribute strongly to who we are as children and what we become as adults. For example, tendencies to excessive worrying or timidity, leadership qualities, risk taking, obedience to authority, all appear to have a constitutional aspect.”
—Stanley Turecki (20th century)