HLA-DQB1

HLA-DQB1

Identifiers Symbols HLA-DQB1; CELIAC1; HLA-DQB; IDDM1 External IDs OMIM: 604305 HomoloGene: 1603 GeneCards: HLA-DQB1 Gene

Gene Ontology
Molecular function	• MHC class II receptor activity
Cellular component	• Golgi membrane • lysosomal membrane • plasma membrane • endosome membrane • ER to Golgi transport vesicle membrane • membrane • transport vesicle membrane • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane • trans-Golgi network membrane • MHC class II protein complex • integral to lumenal side of endoplasmic reticulum membrane
Biological process	• immunoglobulin production involved in immunoglobulin mediated immune response • humoral immune response mediated by circulating immunoglobulin • immune response • cytokine-mediated signaling pathway • antigen processing and presentation of exogenous peptide antigen via MHC class II • T cell costimulation • T cell receptor signaling pathway • interferon-gamma-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3119 14961 Ensembl ENSG00000179344 ENSMUSG00000073421 UniProt P01920 P14483 RefSeq (mRNA) NM_001243961 NM_207105 RefSeq (protein) NP_001230890 NP_996988 Location (UCSC) Chr 6:
32.63 – 32.64 Mb Chr 17:
34.26 – 34.27 Mb PubMed search

Major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1, is a human gene and also denotes the genetic locus that contains this gene. The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.