HLA-B48

HLA-B48 (B48) is an HLA-B serotype. The serotype identifies the more common HLA-B*48 gene products. B48 is most common along the West Pacific Rim, Americas indigeonous peoples and Northern Eurasians. B*4801 is part of a group of alleles including B*4201 that share Intron 1 sequence with B*0702, which is common over Western and Central Asia, and has a distribution indicating an early and long presence in Eurasian humans. A*48 appears to be the result of a recombination event that occurred early in the settlement history of Central Asia that then spread eastward into the NW Pacific rim and the New World. (For terminology help see: HLA-serotype tutorial)