History
One of the first "eradication protocols," if not the first, was the protocol used by Barry Marshall to treat his own gastritis, which developed following intentional ingestion of H. pylori culture. He used bismuth salt and metronidazole. This treatment effectively cured his gastritis and eliminated the H. pylori infection. But in terms of modern eradication protocol definition, which requires not only occasional ability to cure the infection, but at least 80% eradication rate, this protocol cannot be described as "eradication protocol" and is not clinically reasonable.
One of the first "modern" eradication protocols was a one week triple therapy, which the Sydney gastroenterologist Thomas Borody formulated in 1987. As of 2006, a standard triple therapy is amoxicillin, clarithromycin and a proton pump inhibitor such as omeprazole, lansoprazole, pantoprazole or esomeprazole. Protocols with metronidazole were also in use.
An example of a fixed-dose combination is PantoPac, containing pantoprazole, clarithromycin, and amoxicillin.
Read more about this topic: Helicobacter Pylori Eradication Protocols
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