Hefner or Heffner, meaning "potter" or "harbor-master", may refer to:
In music:
- Hefner (band), British band
People with the surname Hefner:
- Jeremy Hefner (born March 11, 1986), MLB pitcher for the New York Mets
- Robert A. Hefner (born 1864), Oilman, Oklahoma Hall of Fame 1949, OK Supreme Court Justice and Mayor of Oklahoma City
- Robert A. Hefner, Jr. (born 1907), Oilman, Oklahoma Hall of Fame 1979 and Golden Gloves Boxer
- Bill Hefner (born 1930), US Representative from North Carolina.
- Christie Hefner (born 1952), former Chairman of Playboy Enterprises, daughter of Hugh Hefner
- Hugh Hefner (born 1926), founder of Playboy Magazine
- Bob Heffner (born 1938 in Pennsylvania) Major League baseball-pitcher
- Don Heffner (b. 1911 in Philadelphia d. 1989), American second-baseman
- Richard Heffner (born 1925), TV talk show host, and professor at Rutgers Institute
- Philip Hefner, Lutheran professor of the theology of evolution