Haplotype

A haplotype (from the Greek: ἁπλοῦς, haploûs, "onefold, single, simple") in genetics is a combination of alleles (DNA sequences) at adjacent locations (loci) on the chromosome that are transmitted together. A haplotype may be one locus, several loci, or an entire chromosome depending on the number of recombination events that have occurred between a given set of loci.

In a second meaning, haplotype is a set of single-nucleotide polymorphisms (SNPs) on a single chromosome of a chromosome pair that are statistically associated. It is thought that these associations, and the identification of a few alleles of a haplotype block, can unambiguously identify all other polymorphic sites in its region. Such information is very valuable for investigating the genetics behind common diseases, and has been investigated in the human species by the International HapMap Project.

Many genetic testing companies use the term 'haplotype' to refer to an individual collection of short tandem repeat (STR) allele mutations within a genetic segment, while using the term 'haplogroup' to refer to the SNP/unique-event polymorphism (UEP) mutations which represents the clade to which a collection of potential haplotypes belong.

Read more about Haplotype:  Haplotype Resolution, Y-DNA Haplotypes From Genealogical DNA Tests, Diversity

Other articles related to "haplotype, haplotypes":

Haplotype - Diversity
... Haplotype diversity is a measure of the uniqueness of a particular haplotype in a given population ... The haplotype diversity (H) is calculated as where is the (relative) haplotype frequency of each haplotype in the sample and is the sample size ... Haplotype diversity is given for each sample ...
Modal Haplotype
... A modal haplotype is an ancestral haplotype derived from the DNA test results of a specific group of people, using genetic genealogy ... The two most commonly discussed modal haplotypes are the Atlantic Modal Haplotype (the most common haplotype in parts of Europe, associated with Haplogroup R1b) and the Cohen Modal ... However, a specific modal haplotype may be determined for any genealogical DNA test-based surname project or other test group ...
Haplogroup R1b (Y-DNA) - Nomenclature
... In Western Europe the STR haplotype known as the Atlantic Modal Haplotype was found to be most common by Wilson et al ... research using RFLP genotyping identified two distinct haplotypes within R-M269 ... the Balkans, Georgia and Turkey) "haplotype 35" or "ht35" was found to be a common form of R-M269, whereas in western Europe "haplotype 15" or "ht15" dominated in frequency ...
HLA B7-DR15-DQ6 - HLA A3-B7-DR15-DQ6
... HLA A3-B7 haplotype frequencies freq Rank in ref. 2.5 Italy 1.6 Greek 1.3 Bulgaria 1.1 1 Cw*0702 (Europe) The gene-allele representation of the haplotype is This is considered now the longest of the widely..The haplotype is nodal in Ireland but is also at high frequency in Switzerland, it has a subnode in the Pasiegos of northern Spain ...
Anti-apolipoprotein Antibodies - Genetics
... disequilbrium in the DRB4*01DRB1*0402DQA1*0301DQB1*0302 haplotype, also called DR4-DQ8 and also the DQA10303DQB1*0301 haplotype, DR4-DQ7.3 ... only DR4(0402)-DQ8 was found, indicating that the entire haplotype is involved ...