Gwin may refer to:
- The former settlement Gwin, California
- An animal character in Cornelia Funke's Inkworld trilogy
- Aaron Gwin, American professional downhill mountain biker
- James S. Gwin (born 1954), United States federal judge
- William M. Gwin (1805–1885), American medical doctor and politician
- Gwin Town, a populated place in the county of Grand Gedeh in Liberia
- Adar Llwch Gwin, giant birds, similar in kind to the griffin, which were given to a warrior named Drudwas ap Tryffin by his fairy wife
- USS Gwin, four ships of this name in the United States Navy
- Robert Gwin, a Welsh Roman Catholic divine