Fictional Characters Surnamed Griffin
- The Griffin family of Family Guy:
- Peter Griffin, father
- Lois Griffin, mother
- Meg Griffin, daughter and oldest child
- Chris Griffin, older son
- Stewie Griffin, younger son
- Brian Griffin, anthropomorphic pet dog
- Francis Griffin, Peter's (adoptive) father
- Thelma Griffin, Peter's mother
- Bertram Griffin, Peter's biological son (though not raised in the Griffin household)
- Griffin (The Invisible Man) (Jack Griffin), fictional character; H. G. Wells's The Invisible Man ("Jack" only in film versions)
- Judge Griffin, a character in the Judge Dredd comic strip
- Maya Griffin, a character in The O.C.
- Sandi Griffin, a character in the animated series Daria
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