Measuring A1C
There are a number of techniques used to measure A1C.
Laboratories use:
- high-performance liquid chromatography (HPLC): The HbA1c result is calculated as a ratio to total hemoglobin by using a chromatogram.
- immunoassay
- Enzymatic
- Capillary Electrophoresis
Point of care (e.g., doctor's surgery) devices use:
- immunoassay
- boronate affinity chromatography
In the United States, A1C testing laboratories are certified by the National Glycohemoglobin Standardization Program (NGSP) to standardise them against the results of the 1993 Diabetes Control and Complications Trial (DCCT). There is an additional percentage scale, Mono S, that is in use by Japan and Sweden.
Read more about this topic: Glycated Hemoglobin
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