Glutamate Carboxypeptidase II - Neurotransmitter Degradation

Neurotransmitter Degradation

For those studying neural based diseases, NAAG is one of the three most prevalent neurotransmitters found in the central nervous system and when it catylizes the reaction to produce glutamate it is also producing another neurotransmitter. Glutamate is a common and abundant excitatory neurotransmitter in the central nervous system; however, if there is too much glutamate transmission, this can kill or at least damage neurons and has been implicated in many neurological diseases and disorders therefore the balance that NAAG peptidase contributes to is quite important.