George Spencer-Churchill may refer to:
- George Spencer-Churchill, 5th Duke of Marlborough (1766–1840)
- George Spencer-Churchill, 6th Duke of Marlborough (1793–1857)
- George Spencer-Churchill, 8th Duke of Marlborough (1844–1892)
- George Spencer-Churchill, Earl of Sunderland (born 1992) is the grandson of 11th Duke of Marlborough
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