Theoretical Models of Genetic Equilibrium
The Hardy-Weinberg principle provides the mathematical framework for genetic equilibrium. Genetic equilibrium itself, whether Hardy-Weinberg or otherwise, provides the groundwork for a number of applications, in including population genetics, conservation and evolutionary biology. With the rapid increase in whole genome sequences available as well as the proliferation of anonymous markers, models have been used to extend the initial theory to all manner of biological contexts. Using data from genetic markers such as ISSRs and RAPDs as well as the predictive potential of statistics, studies have developed models to infer what processes drove the lack of equilibrium. This includes local adaptation, range contraction and expansion and lack of gene flow due to geographic or behavioral barriers, although equilibrium modeling has been applied to a wide range of topics and questions.
Difficulties with genetic equilibrium modeling have led to developments in the field. Because allelic dominance can disrupt predictions of equilibrium, some models have moved away from using genetic equilibrium as an assumption. Instead of the traditional F-statistics, they make use of Bayesian estimates. Holsinger et al. developed an analog to FST, called theta. Studies have found Bayesian estimates to be better predictors of the patterns observed. However, genetic equilibrium-based modeling remains a tool in population and conservation genetics-it can provide invaluable information about previous historical processes.
Read more about this topic: Genetic Equilibrium
Famous quotes containing the words theoretical, models, genetic and/or equilibrium:
“The desire to serve the common good must without fail be a requisite of the soul, a necessity for personal happiness; if it issues not from there, but from theoretical or other considerations, it is not at all the same thing.”
—Anton Pavlovich Chekhov (1860–1904)
“Friends broaden our horizons. They serve as new models with whom we can identify. They allow us to be ourselves—and accept us that way. They enhance our self-esteem because they think we’re okay, because we matter to them. And because they matter to us—for various reasons, at various levels of intensity—they enrich the quality of our emotional life.”
—Judith Viorst (20th century)
“We cannot think of a legitimate argument why ... whites and blacks need be affected by the knowledge that an aggregate difference in measured intelligence is genetic instead of environmental.... Given a chance, each clan ... will encounter the world with confidence in its own worth and, most importantly, will be unconcerned about comparing its accomplishments line-by-line with those of any other clan. This is wise ethnocentricism.”
—Richard Herrnstein (1930–1994)
“They who feel cannot keep their minds in the equilibrium of a pair of scales: fear and hope have no equiponderant weights.”
—Horace Walpole (1717–1797)