Natural Occurrence
Naturally occurring fusion genes are most commonly created when a chromosomal translocation replaces the terminal exons of one gene with intact exons from a second gene. This creates a single gene which can be transcribed, spliced, and translated to produce a functional fusion protein. Many important cancer-promoting oncogenes are fusion genes produced in this way.
Examples include:
- Gag-onc fusion protein
- Bcr-abl fusion protein
- Tpr-met fusion protein
Antibodies are fusion proteins produced by VDJ recombination.
Read more about this topic: Fusion Protein
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