Fusion Protein
Fusion proteins or chimeric proteins are proteins created through the joining of two or more genes which originally coded for separate proteins. Translation of this fusion gene results in a single polypeptide with functional properties derived from each of the original proteins. Recombinant fusion proteins are created artificially by recombinant DNA technology for use in biological research or therapeutics. Chimeric mutant proteins occur naturally when a complex mutation, such as a chromosomal translocation, tandem duplication, or retrotransposition creates a novel coding sequence containing parts of the coding sequences from two different genes. Naturally occurring fusion proteins are commonly found in cancer cells, where they may function as oncoproteins. The bcr-abl fusion protein is a well-known example of an oncogenic fusion protein, and is considered to be the primary oncogenic driver of chronic myelogenous leukemia.
Read more about Fusion Protein: Functions, Recombinant Technology, Natural Occurrence
Other articles related to "proteins, protein, fusion proteins, fusion protein, fusion":
... identical to the body's own key signalling proteins ... Examples are the blood-production stimulating protein erythropoetin, or the growth-stimulating hormone named (simply) "growth hormone" or biosynthetic human insulin and its analogues ... Receptor constructs (fusion proteins), usually based on a naturally-occurring receptor linked to the immunoglobulin frame ...
... model is an interaction with the unfolded fusion protein (TaT) and the membrane through electrostatic interactions, which disrupt the membrane enough to allow ... After internalization, the fusion protein refolds due the chaperon system ... acid side-chains, may be common and perhaps central to the functions of many membrane protein functions ...
... Tpr-met fusion protein is an oncogene fusion protein consisting of TPR and MET. ...
... MBP is used to increase the solubility of recombinant proteins expressed in E ... In these systems, the protein of interest is often expressed as a MBP-fusion protein, preventing aggregation of the protein of interest ... as an affinity tag for purification of recombinant proteins ...
... Naturally occurring fusion genes are most commonly created when a chromosomal translocation replaces the terminal exons of one gene with intact exons from a second gene ... can be transcribed, spliced, and translated to produce a functional fusion protein ... Many important cancer-promoting oncogenes are fusion genes produced in this way ...
Famous quotes containing the words protein and/or fusion:
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—Alfred Gingold, U.S. humorist. Items From Our Catalogue, “Tofu Innersoles,” Avon Books (1982)
“No ... the real American has not yet arrived. He is only in the Crucible, I tell you—he will be the fusion of all races, perhaps the coming superman.”
—Israel Zangwill (1864–1926)