Frank Ryan may refer to:
- Frank Ryan (cricketer) (1888–1954), English cricketer
- Frank Ryan (tenor) (1900–1965), Irish opera singer
- Frank Ryan (Irish republican) (1902–1944), member of the Irish Republican Army and the Republican Congress
- Frank Ryan (American football) (born 1936), retired American football quarterback
- Frank "Dunie" Ryan (1942–1984), Canadian mobster
- Frank Ryan (doctor) (1960–2010), American plastic surgeon
- Frank Ryan (sportscaster) (1899–1961), publicity director and sports announcer
- Frank Ryan (athlete), United States national shot put champion