Pathologic Findings
Pathologic changes are recognized by the detection of either hyperfluorescence or hypofluroescence.
Causes of hyperfluorescence:
- leaking defects (i.e. capillary leakage, aneurysm, neovascularization)
- pooling defects
- staining
- transmission (filling) defects
- abnormal vasculature
Causes of hypofluorescence:
- blocking defect (i.e. blood)
- filling defect (capillary blockage)
Fluorescein angiography is used by physicians specializing in the treatment of eye diseases (ophthalmologists) to evaluate the vasculature of the retina, choroid, optic disc, and iris. Among the common groups of ophthalmologic disease, fluorescein angiography can detect diabetic retinopathy (neovascularization), vein occlusions, retinal artery occlusions, edema of the optic disc, and tumors. Additionally, the transit time (the period between injection of the dye and when it appears in the examined blood vessels) can provide an objective measurement of the rate of blood flow through the imaged blood vessels.
Read more about this topic: Fluorescein Angiography
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