Liver Toxicity
In some patients pemoline is suspected of causing hepatotoxicity, so the FDA recommended that regular liver tests should be performed on those treated with it. Since receiving FDA approval in 1975, it has been linked with 21 cases of liver failure, of which 13 resulted in liver replacement or death.
In March 2005 Abbott Laboratories and generic manufacturers withdrew pemoline from the market due to concerns about the liver toxicity risk.
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Famous quotes containing the word liver:
“A life-worshipper’s philosophy is comprehensive.... He is at one moment a positivist and at another a mystic: now haunted by the thought of death ... and now a Dionysian child of nature; now a pessimist and now, with a change of lover or liver or even the weather, an exuberant believer that God’s in his heaven and all’s right with the world.”
—Aldous Huxley (1894–1963)