Fessenden, an English surname dating back to the 17th century, can refer to:
People:
- Francis Fessenden (1839-1907), American Civil War major general, lawyer and politician, son of William P. Fessenden
- James Deering Fessenden (1833-1882), American Civil War brigadier general, son of William P. Fessenden
- Larry Fessenden (born 1963), American film director
- Reginald Fessenden (1866-1932), Canadian radio pioneer
- Richard Fessenden, chemistry professor, University of Notre Dame
- Samuel Fessenden (1784-1869), American abolitionist; father of Samuel Clement Fessenden, T. A. D. Fessenden, and William P. Fessenden
- Samuel Fessenden (lawyer) (1847-1908), lawyer and politician
- Samuel C. Fessenden (1815-1882), judge and U.S. Representative from Maine (1861-63)
- Sterling Fessenden (1875-1943), American lawyer, chairman of the Shanghai Municipal Council (1923-29)
- T. A. D. Fessenden (1826-1868), attorney, and briefly U.S. Representative from Maine
- Thomas Green Fessenden (1771-1837), American author and editor
- William P. Fessenden (1806-1869), U.S. senator and Lincoln's Treasury Secretary
- Fessenden Nott Otis (1825-c. 1900), American pioneer in the medical field of urology
Places:
- Fessenden, North Dakota, a city
- 15939 Fessenden, an asteroid named after Reginald Fessenden
- Fessenden, a fictional princedom in Melanie Rawn's Dragon Prince fantasy novel series
Other uses:
- USS Fessenden (DE-142), a destroyer escort which served in World War II, named in honor of Reginald Fessenden
- Fessenden School, a private day and boarding school for boys in West Newton, Massachusetts
- Fessenden (guitars), a pedal steel guitar manufacturer
- Fessenden oscillator, an underwater sound projector