Estrin is a surname, and may refer to:
- Dan Estrin (born 1976), guitarist
- Deborah Estrin, Professor of Computer Science, University of California Los Angeles
- Gerald Estrin, Professor Emeritus of Computer Science, University of California Los Angeles
- Joshua Estrin (born 1970)
- Judith Estrin, American business executive
- Marc Estrin (born 1939) American writer and political activist
- Morton Estrin (born 1923), American pianist
- Yakov Estrin (1923–1987), Russian chess player
- Herman Estrin (1915–1999), Prof. of Literature, Newark College of Engineering
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