ERCC1

ERCC1

Identifiers Symbols ERCC1; COFS4; RAD10; UV20 External IDs OMIM: 126380 MGI: 95412 HomoloGene: 1501 GeneCards: ERCC1 Gene

Gene Ontology
Molecular function	• single-stranded DNA specific endodeoxyribonuclease activity • damaged DNA binding • single-stranded DNA binding • protein binding • protein C-terminus binding • protein domain specific binding • structure-specific DNA binding
Cellular component	• nucleotide-excision repair complex • nuclear chromosome, telomeric region • nucleus • nucleoplasm • nucleolus • cytoplasm
Biological process	• nucleotide-excision repair, DNA damage removal • pyrimidine dimer repair by nucleotide-excision repair • replicative cell aging • DNA repair • transcription-coupled nucleotide-excision repair • nucleotide-excision repair • nucleotide-excision repair, DNA incision, 3'-to lesion • nucleotide-excision repair, DNA incision, 5'-to lesion • double-strand break repair • DNA recombination • mitotic recombination • syncytium formation • response to oxidative stress • germ cell development • spermatogenesis • response to nutrient • cell proliferation • male gonad development • UV protection • response to sucrose stimulus • response to X-ray • multicellular organismal aging • negative regulation of telomere maintenance • post-embryonic hemopoiesis • multicellular organism growth • negative regulation of apoptotic process • isotype switching • oogenesis • embryonic organ development • chromosome organization
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2067 13870 Ensembl ENSG00000012061 ENSMUSG00000003549 UniProt P07992 P07903 RefSeq (mRNA) NM_001166049 NM_001127324 RefSeq (protein) NP_001159521 NP_001120796 Location (UCSC) Chr 19:
45.91 – 45.98 Mb Chr 7:
19.34 – 19.36 Mb PubMed search

DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene.