Ecco may refer to:
- Ecco Press, an imprint of the multinational publisher HarperCollins
- ECCO, a Danish shoe manufacturer
- Eighteenth Century Collections Online, a digital library of books published in the British Empire between 1701 and 1800
- Encyclopedia of Chinese Chess Openings, a classification of all possible openings in Chinese Chess
- Earth Coincidence Control Office, a concept of super intelligent entities described by John C. Lilly
- Ecco Pro, a software package
- Ecco the Dolphin, a 1992 video game
- European Cancer Organisation, a non-profit oncology association