- Charlton Heston as Stuart Graff
- Ava Gardner as Remy Royce-Graff
- George Kennedy as Lou Slade
- Lorne Greene as Sam Royce
- Geneviève Bujold as Denise Marshall
- Richard Roundtree as Miles Quade
- Marjoe Gortner as Jody Joad
- Barry Sullivan as Dr. Willis Stockle
- Lloyd Nolan as Dr. James Vance
- Victoria Principal as Rosa Amici
- Walter Matthau as "Drunk" (credited as "Walter Matuschanskayasky").
- Monica Lewis as Barbara
- Gabriel Dell as Sal Amici
- Pedro Armendáriz, Jr. as Emilio Chavez
- Lloyd Gough as Bill Cameron
- John Randolph as (Mayor) Lewis
- Kip Niven as Walter Russell
- Scott Hylands as Max
- Tiger Williams as Corry Marshall
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- Donald Moffat as Dr. Harvey Johnson
- Jesse Vint as Buck
- Alan Vint as Ralph
- Michael Richardson as Hank
- John Elerick as Carl Leeds
- John S. Ragin as (Chief Inspector)
- George Murdock as (Colonel)
- Donald Mantooth as Sid
- Lionel Johnston as Sandy
- Alex A. Brown as (Pool Player)
- Bob Cunningham as Dr. Frank Adams
- John Dennis as Brawny Foreman
- Gene Dynarski as Fred
- Bob Gravage as (Farmer) Mr. Griggs
- H.B. Haggerty as (Pool Player)
- Tim Herbert as (Las Vegas Man)
- Dave Morick as (Technician)
- Inez Pedroza as Lorra
- Josh Albee as (Boy w/Radio) (uncredited)
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