Drug Delivery


Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Drug release is from: diffusion, degradation, swelling, and affinity-based mechanisms. Most common routes of administration include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes. Many medications such as peptide and protein, antibody, vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective. For this reason many protein and peptide drugs have to be delivered by injection or a nanoneedle array. For example, many immunizations are based on the delivery of protein drugs and are often done by injection.

Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. In order to achieve efficient targeted delivery, the designed system must avoid the host's defense mechanisms and circulate to its intended site of action. Types of sustained release formulations include liposomes, drug loaded biodegradable microspheres and drug polymer conjugates.

Other articles related to "drug delivery, delivery":

3m Tape - History - Expansion
... Another division of the Health Care business, Drug Delivery Systems remains with 3M ... The Drug Delivery System division continues to contract manufacture inhalants and transdermal drug delivery systems and has now taken on manufacture of the products whose licenses were sold during the ...
Acoustic Targeted Drug Delivery
... Acoustic targeted drug delivery (ATDD) is a method that uses ultrasound energy to enhance the transport of molecules into and/or across specific tissues. 0-30 watts/cm2 The use of ATDD in conjunction with local drug delivery by injection, topical application and convection enhanced delivery shows promise to significantly enhance the treatment ...
List Of Pharmaceutical Sciences Journals
... Advanced Drug Delivery Reviews Molecular Pharmaceutics Drug Delivery Drug Development and Industrial Pharmacy European Journal of Pharmaceutical Sciences ...
Synthetic Biodegradable Polymer
... in the fields of tissue engineering and controlled drug delivery ... In the field of controlled drug delivery, biodegradable polymers offer tremendous potential either as a drug delivery system alone or in conjunction to functioning as a medical ...

Famous quotes containing the words delivery and/or drug:

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