Clinical Significance
Because of the epigenetic effects of the DNMT family, some DNMT inhibitors are under investigation for treatment of some cancers :
- Vidaza (5-azacitidine) in a phase II trial for AML
- Dacogen (decitabine) in phase III trials for AML and CML
Read more about this topic: DNA Methyltransferase
Famous quotes containing the word significance:
“Of what significance the light of day, if it is not the reflection of an inward dawn?—to what purpose is the veil of night withdrawn, if the morning reveals nothing to the soul? It is merely garish and glaring.”
—Henry David Thoreau (1817–1862)