Spontaneous
Spontaneous or accidental DNA fragmentation is fragmentation that gradually accumulates in a cell. It can be measured by e.g. Comet assay.
The degree of DNA fragmentation can predict outcomes for in vitro fertilization (IVF) and its expansion intracytoplasmic sperm injection (ICSI). The sperm chromatin dispersion test (SCD) and TUNEL assay are both effective in detecting sperm DNA damage. Using bright-field microscopy, the SCD test appears to be more sensitive than the TUNEL assay.
Its main units of measurement is DNA fragmentation index (DFI). A DFI of 20% or more significantly reduces the success rates after ICSI.
Read more about this topic: DNA Fragmentation
Famous quotes containing the word spontaneous:
“Our spontaneous action is always the best. You cannot, with your best deliberation and heed, come so close to any question as your spontaneous glance shall bring you.”
—Ralph Waldo Emerson (1803–1882)
“If learning to read was as easy as learning to talk, as some writers claim, many more children would learn to read on their own. The fact that they do not, despite their being surrounded by print, suggests that learning to read is not a spontaneous or simple skill.”
—David Elkind (20th century)
“If an educational act is to be efficacious, it will be only that one which tends to help toward the complete unfolding of life. To be thus helpful it is necessary rigorously to avoid the arrest of spontaneous movements and the imposition of arbitrary tasks.”
—Maria Montessori (1870–1952)