Symptoms
Dent's disease often produces symptoms of:
- Extreme thirst combined with dehydration, which leads to frequent urination
- Nephrolithiasis (kidney stones)
- Hypercalciuria (high urine calcium - >300 mg/d or >4 mg/kg per d) with normal levels blood/serum calcium)
Dent's disease may also be associated with:
- Aminoaciduria (amino acids in urine)
- Phosphaturia (phosphate in urine)
- Glycosuria (glucose in urine)
- Kaliuresis (potassium in urine)
- Hyperuricosuria (excessive amounts of uric acid in the urine)
- Impaired urinary acidification
- Rickets
In a study of 25 patients with Dent's disease, 9 of 15 men, and one of 10 women suffered end-stage renal failure by the age of 47.
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