Adverse Effects
The most common side effects include infections of the urinary and respiratory tracts, cataracts, constipation, rashes. and joint pain. A small study found a slightly increased risk of cancer and severe infections, but these results did not reach statistical significance. Another trial showed significantly increased rates of eczema and hospitalization due to infections of the skin. It has been proposed that the increase in infections under denosumab treatment might be connected to the role of RANKL in the immune system. RANKL is expressed by T helper cells, and is thought to be involved in dendritic cell maturation.
Read more about this topic: Denosumab
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