Adverse Effects
The most common side effects include infections of the urinary and respiratory tracts, cataracts, constipation, rashes. and joint pain. A small study found a slightly increased risk of cancer and severe infections, but these results did not reach statistical significance. Another trial showed significantly increased rates of eczema and hospitalization due to infections of the skin. It has been proposed that the increase in infections under denosumab treatment might be connected to the role of RANKL in the immune system. RANKL is expressed by T helper cells, and is thought to be involved in dendritic cell maturation.
Read more about this topic: Denosumab
Famous quotes containing the words adverse and/or effects:
“[Religious establishment] is adverse to the diffusion of the light of Christianity ... [because] with an ignoble and unchristian timidity it would [be] circumscribed, with a wall of defence, against the encroachments of error.”
—James Madison (1751–1836)
“Whereas Freud was for the most part concerned with the morbid effects of unconscious repression, Jung was more interested in the manifestations of unconscious expression, first in the dream and eventually in all the more orderly products of religion and art and morals.”
—Lewis Mumford (1895–1990)