Landmarks in History of Vaccines
| Year | Landmark |
|---|---|
| 1000 | Chinese practicing variolation |
| 1545 | Smallpox epidemic in India |
| 1578 | Whooping cough epidemic in Paris |
| 1625 | Early smallpox in North America |
| 1633 | Colonial epidemic |
| 1661 | Kangxi Emperor gives royal support for inoculation. |
| 1676 | Thomas Sydenham documents Measles infection |
| 1676 | "The Indian Plague" in Iroquois documented by Louis de Buade de Frontenac |
| 1694 | Queen Mary II dies of smallpox on 28 December. |
| 1699 | Yellow Fever outbreak in the American Colonies. |
| 1718 | Lady Mary Montagu had her 6-year old son variolated in Constantinople by Dr. Charles Maitland |
| 1721 | Lady Mary Montagu had her 2-year old daughter variolated in England by Dr. Charles Maitland |
| 1736 | Benjamin Franklin’s 4-year-old son dies of smallpox. |
| 1740 | Friedrich Hoffmann gives first description of rubella |
| 1757 | Francis Home demonstrates infectious nature of measles |
| 1760 | Edward Jenner learns about smallpox protection from a milkmaid |
| 1796 | Edward Jenner introduces smallpox vaccine |
| 1800 | Benjamin Waterhouse brings smallpox vaccination to United States |
| 1817 | Cholera pandemic begins |
| 1817 | Panum studies epidemiology of measles in Faroe Islands |
| 1854 | Filippo Pacini isolates Vibrio cholerae |
| 1874 | A compulsory smallpox vaccination and revaccination law goes into in effect in Germany |
| 1880 | Louis Pasteur develops attenuated fowl cholera vaccine |
| 1881 | Louis Pasteur and George Sternberg independantly discover Pneumococcus |
| 1882 | Koch isolates tubercle bacilli |
| 1882 | Louis Pasteur successfully prevents rabies in Joseph Meister by post-exposure vaccination |
| 1888 | Institut Pasteur inaugurated on 14 November |
| 1890 | Shibasaburo Kitasato and Emil von Behring immunize guinea pigs with heat-treated diphtheria toxin |
| 1892 | Pfeiffer discovers Pfeiffer influenza bacillus |
| 1894 | First major documented polio outbreak in the United States occurrs in Rutland County, Vermont |
| 1896 | Koch discovers Cholera vibrio |
| 1899 | Yellow fever plagues Panama Canal workers resulting in transfer of project rights from France to United States |
| 1900 | Walter Reed discovers cause of yellow fever after studying it in Cuba |
| 1906 | Jules Bordet and Octave Gengou isolate Bordetella pertussis |
| 1908 | Karl Landsteiner and Erwin Popper discover poliovirus |
| 1924 | BCG is introduced as live tuberculosis vaccine |
| 1935 | Max Theiler develops live attenuated 17D yellow fever vaccine |
| 1945 | Chick embryo allantoic fluid-derived influenza vaccine is developed |
| 1949 | John Enders cultivates poliovirus in tissue culture |
| 1955 | Jonas Salk introduces injectable inactivated polio vaccine |
| 1961 | Albert Sabin develops oral live attenuated polio vaccine |
| 1960-1969 | Live attenuated vaccines for Measles, Mumps and Rubella are developed |
| 1974-1984 | Polysaccharide vaccines for Meningococcus, Pneumococcus and Hemophilus are developed |
| 1981 | Smallpox declared eradicated worldwide |
| 1981 | Hepatitis B vaccine is licenced |
| 1983 | Hemophilus influenzae carbohydrate-protein conjugate is developed |
| 1986 | Yeast-derived recombinant hepatitis B vaccine is licensed |
| 1994 | Polio declared eliminated from Americas |
| 2002 | Polio declared eradicated from Europe |
| 2012 | Polio declared eliminated from India |
Read more about this topic: Delivery System, History
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—George Gordon Noel Byron (1788–1824)
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