Cxcr4

CXCR4

Identifiers Symbols CXCR4; CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM External IDs OMIM: 162643 MGI: 109563 HomoloGene: 20739 IUPHAR: CXCR4 ChEMBL: 2107 GeneCards: CXCR4 Gene

Gene Ontology
Molecular function	• actin binding • G-protein coupled receptor activity • protein binding • coreceptor activity • C-X-C chemokine receptor activity • ubiquitin protein ligase binding • myosin light chain binding • ubiquitin binding
Cellular component	• cytoplasm • plasma membrane • external side of plasma membrane • cell surface • integral to membrane • cytoplasmic membrane-bounded vesicle • growth cone • cell leading edge • cytoplasmic vesicle
Biological process	• activation of MAPK activity • patterning of blood vessels • response to hypoxia • ameboidal cell migration • neuron migration • dendritic cell chemotaxis • apoptotic process • inflammatory response • G-protein coupled receptor signaling pathway • elevation of cytosolic calcium ion concentration • germ cell development • brain development • motor neuron axon guidance • germ cell migration • response to virus • viral reproduction • virus-host interaction • calcium-mediated signaling • entry into host cell • regulation of cell migration • T cell proliferation • myelin maintenance • positive regulation of oligodendrocyte differentiation • regulation of chemotaxis • neural precursor cell proliferation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7852 12767 Ensembl ENSG00000121966 ENSMUSG00000045382 UniProt P61073 P70658 RefSeq (mRNA) NM_001008540.1 NM_009911.3 RefSeq (protein) NP_001008540.1 NP_034041.2 Location (UCSC) Chr 2:
136.87 – 136.88 Mb Chr 1:
128.59 – 128.59 Mb PubMed search

C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene.