Cuffe may refer to:
- Charles Cuffe (1914–1972), Irish cricketer
- Ciaran Cuffe (born 1963), Irish Green Party politician
- Ellen Cuffe, Countess of Desart (1857–1933), Irish politician and company director
- Hamilton Cuffe, 5th Earl of Desart, KP, KCB, PC (1848–1934), British peer and solicitor
- Henry Cuffe (1563–1601), English author and politician, executed during the reign of Queen Elizabeth I of England for treason
- James Cuffe, 1st Baron Tyrawley (1747–1821), Irish peer and politician
- James Cuffe (died 1678) (died 1678), Irish politician
- James Cuffe (died 1762) (1707–1762), of Elmhall and Ballinrobe, was an Irish landowner in County Mayo
- James Cuffe (died 1828) (1778–1828), Irish MP, elected to the Irish House of Commons for Tulsk in 1800
- John Cuffe (1880–1931), Australian-born English cricketer and footballer
- John Cuffe, 3rd Earl of Desart (1818–1865), Irish Conservative politician
- Lady Charlotte Wheeler Cuffe (née Williams) (1867–1967), Irish botanic artist and collector
- Michael Cuffe (1694–1744), Irish Member of Parliament
- Mike Cuffe, Republican member of the Montana Legislature
- Nikita Cuffe, Australian water polo player
- Selena Cuffe, née Saunders (born 1975), African-American businesswoman
Read more about Cuffe: See Also