Cuca may refer to:
- Cuca, Argeş, a commune in Argeș County, Romania
- Cuca, Galaţi, a commune in Galaţi County, Romania
- Cuca (band), a Mexican rock group
- Cuca beer, an Angolan brand of beer
- Cuca (footballer) (born 1963), former Brazilian football player, and manager
- Cuca Records, a former record label in Sauk City, Wisconsin, United States
- Cuca or Cuco, a monster in Brazilian folklore
- Cambridge University Conservative Association, a Conservative political society for students at Cambridge University, England
- Charlotte United Christian Academy, a private Christian school in Charlotte, North Carolina, United States