As an acronym, CRE may refer to:
- Center for Regulatory Effectiveness, a US lobbying firm
- Chemical Reaction Engineering
- Commission for Racial Equality, a body handling racial equality in United Kingdom
- Cumann Rothaíochta na hÉireann
- Common Recruitment Examination, an examination for recruiting civil servants in Hong Kong
- CRE is the ICAO airline designator for Cree Airways Corporation, Canada
- Commercial Real Estate
- cAMP response element
- Castle Rock Entertainment
- CR England a global transportation company
- Carbapenem resistant enterobacteriaceae an antibiotic resistant bacteria family
As an abbreviation, Cre may refer to:
- Cre recombinase, an enzyme that catalyzes a type of site-specific homologous recombination
- I-CreI, a homing endonuclease
- cis-acting replication element