People
- Richard Bourke, 6th Earl of Mayo - Viceroy of India 1869-72.
- Browne family
- Admiral William Brown (1777 to 1857) - born in Foxford, founder of the Argentine Navy.
- Patrick Browne (1720–1790) - doctor and botanist of Jamaica.
- Brian Rua U'Cearbhain - 17th century prophet from Erris.
- Willie Corduff - Winner of Goldman Environmental Prize 2007.
- Jerry Cowley - GP of note.
- Michael Davitt - founder of the Land League, born in Mayo. The bridge to Achill is named after him as well as Castlebar's local secondary school (Davitt College).
- Richard Douthwaite - economist and campaigner from Westport
- Frank Durkan - New York City human rights attorney best known for having represented numerous members of the Provisional Irish Republican Army (IRA), including avowed gun-runner and pivotal North American member of the IRA George Harrison, who stood trial, and was acquitted, in 1982 and Desmond Mackin - accused of shooting a British soldier.
- Earl of Mayo (Bourke)
- [Michael Feeney (MBE) Chairman and Founder of Mayo Peace Park.
- Seán Flanagan (1922– 1993) - senior Fianna Fáil politician and Gaelic footballer. He served under Taoiseach Jack Lynch as Minister for Health (1966–1969) and Minister for Lands (1969–1973).
- Adrian Flannelly - Irish Radio Network host from 1970.
- Flidais - the heroine of the Ulster Cycle Erris legend of the Táin Bó Flidhais.
- James Owen Hannay aka George A. Birmingham - author of such novels about County Mayo as The Seething Pot (1905) and Hyacinth (1906).
- John Healy - author and journalist (1930–1991).
- Enda Kenny - politician, leader of Fine Gael since 2002 and Taoiseach of Ireland (2011–present).
- Marquess of Sligo (Browne)
- Ciarán McDonald - Gaelic football player.
- John McDonnell (born July 2, 1938) - athletics coach. He has won more national championships (42) than any coach in any sport in the history of American collegiate athletics.
- Paul O'Dwyer - President of New York City Council, prominent New York City human rights attorney, supporter of Irish nationalism, and defender of several Irish Republican Army gunmen from deportation, including "The Fort Worth Five" and Vincent Conlon.
- William O'Dwyer - mayor of New York City from 1946–1950.
- Bernard O'Hara (b. 1945) - Irish historian.
- Gráinne O'Malley - 16th century pirate queen and chieftain of the clan O’Malley, also known as Granuaile.
- Pat Rabbitte, former leader of the Labour Party was born in Woodstock near Ballindine.
- Michael Ring - Fine Gael politician.
- Mary Robinson (born in Ballina, 1944) — first female President of Ireland (1990–1997), and United Nations High Commissioner for Human rights.
- Aoibhinn Ní Shúilleabháin (born in Carnacon in 1983) - winner of the 2005 Rose of Tralee contest. She is the 47th Rose and the first from County Mayo.
- Frank Stagg - IRA Hunger striker.
- Louis Walsh (born 5 August 1952) - pop music manager.
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