Cobe or COBE may refer to:
- COBE (architectural firm), a Danish architectural firm
- Cosmic Background Explorer (COBE), a satellite dedicated to studying cosmic microwave background radiation
- 9997 COBE, a main belt asteroid
- Harry Cobe, an American racecar driver
- Cobe Jones, a Major League Baseball player
- Cobe Trophy Race, an auto race held in 1910 and 1911