CMF, a three letter acronym, may stand for:
- California Medical Facility, a male-only state prison in CA, USA
- Campus MovieFest, the world's largest student film festival
- Centre of mass frame in mechanics
- Certificate of Management Fundamentals, a management certification from the Commonwealth of Kentucky.
- Chaikin Money Flow, a technical stock chart indicator
- Chern Medal Foundation, an organization that bestows the Chern Medal Award in mathematics
- Christian Medical Fellowship, an evangelical, interdenominational organisation that links together Christian doctors and medical students in the UK
- IATA code for Chambéry Airport, in Savoie, France
- The Citizens Military Forces, historic reserve units of the Australian Army
- Color matching fields or functions, a triplet of spectral sensitivity curves in color vision modeling. See CIE 1931 color space#Color matching functions
- Content Management Framework for customizing management of media content
- Combined Maritime Forces, Naval Force of United Nations
- Country Music Foundation, a non-profit, educational organisation, operating The Country Music Hall of Fame and Museum
- Creative Music File, an Adlib/MIDI hybrid music format developed by Creative Labs
- Cyclophosphamide, methotrexate and fluorouracil, a chemotherapy regimen commonly used in treating breast cancer
- Canada Media Fund, a not-for-profit public-private partnership which financially supports the creation of Canadian television and new media
- The Claretians - Congregatio Missionariorum Filiorum