CLE may refer to:
- Current-limiting element, a fuse designed to limit current in power systems
- Central Landing Establishment
- Chemical Langevin equation, a stochastic ordinary differential equation
- The stock symbol for Claire's, a retailer of accessories and jewelry to girls and young women
- Cleveland, Ohio
- IATA airport code for Cleveland Hopkins International Airport
- The Cleveland Weather Forecast Office of the U.S. National Weather Service
- The Cleveland Indians, Browns, or Cavaliers
- Continuing legal education, the professional education of lawyers that takes place after their initial admission to the bar
- Continuous lumbar epidural infusion, a common type of epidural anesthesia
- Leukoencephalopathy with vanishing white matter
- Chu–Liu–Edmonds algorithm, an algorithm for finding optimal branchings in graph theory