Chiles may refer to:
People:
- Adrian Chiles (born 1967), British TV and radio presenter
- Eddie Chiles (1910–93), American businessman
- Henry G. Chiles, Jr. (born 1938), retired United States Navy four star admiral
- Jackie Chiles, fictional attorney on the American television series Seinfeld
- James Chiles (1802-1883), Missouri State Senator, granduncle of Harry S. Truman
- James Chiles (outlaw) (died 1873), Confederate outlaw who rode with William Quantrill's gang, son of Senator Chiles and uncle of President Truman
- Colonel Joseph Chiles, (1810–1885), an early California pioneer and guide
- Lawton Chiles (1930–98), American politician
- Lois Chiles (born 1947), American actress and model
- Marcellus H. Chiles (1895–1918), American soldier, World War I Medal of Honor recipient
- Pearce Chiles (1899–?), early American baseball player
- Rich Chiles (born 1949), former Major League Baseball outfielder
- Walter Chiles (died 1653), Virginia colonial politician
Other uses:
- Chiles (volcano), an extinct volcano in Ecuador
- Chiles Center, a multi-purpose arena in Portland, Oregon
- New Mexico Chiles, an American soccer club