Central Drug Research Institute - Combinatorial Synthesis & High Throughput Screening

Combinatorial Synthesis & High Throughput Screening

The generation of molecular diversity and its potential to facilitate the drug discovery process has recently attracted enormous attention. The institute has made an endeavour in this direction by setting up in-house facilities for both Combinatorial chemistry and High throughput screening (HTS) as tools in the Institute's drug discovery programme. This central facility comprise a Multiple organic synthesizer 496 MOSA for combinatorial synthesis and an Automated Robotics High Throughput Screening system BMG Polar Star Galaxy with optional accessories.

The technical infrastructure comprises the national level facilities, viz. National Laboratory Animal Centre (NLAC), Regional Sophisticated Instrumentation Centre (RSIC) and National Information Centre for Drugs & Pharmaceuticals (NICDAP). These facilities had been created at CDRI with financial support from Departments of Science & Technology, Biotechnology or Scientific & Industrial Research in recognition of the fact that this Institute already had the required expertise in these areas. These facilities cater to the needs of individual researchers, as well as academia, research institutions and industry.

The other technical infrastructure comprises specialised facilities viz Biometry and statistics, Instruments maintenance, Glass blowing, R&D planning, IPR protection, Licensing, International coordination, etc.

The high throughput Screening facility is now upgraded to High content facility to undertake mechanism of action molecules under discovery pipeline and hit to lead conversion. The facility is now fully equipped to undertake wide variety of assays including imaging based analysis. This is first facility in country which has scientific expertise in cell imaging, quantitative image analysis, si-RNA knockdown assays as well as small molecule screening assays.