CD44

CD44

Identifiers Symbols CD44; CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1 External IDs OMIM: 107269 MGI: 88338 HomoloGene: 508 GeneCards: CD44 Gene

Gene Ontology
Molecular function	• hyalurononglucosaminidase activity • transmembrane signaling receptor activity • protein binding • collagen binding • hyaluronic acid binding
Cellular component	• plasma membrane • integral to plasma membrane • external side of plasma membrane • cell surface • basolateral plasma membrane
Biological process	• branching involved in ureteric bud morphogenesis • wound healing involved in inflammatory response • carbohydrate metabolic process • cell-matrix adhesion • positive regulation of gene expression • Wnt receptor signaling pathway • cell-cell adhesion • cytokine-mediated signaling pathway • glycosaminoglycan metabolic process • hyaluronan metabolic process • hyaluronan catabolic process • positive regulation of peptidyl-serine phosphorylation • positive regulation of heterotypic cell-cell adhesion • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of DNA damage response, signal transduction by p53 class mediator • small molecule metabolic process • cellular response to fibroblast growth factor stimulus • positive regulation of peptidyl-tyrosine phosphorylation • cartilage development • interferon-gamma-mediated signaling pathway • branching involved in prostate gland morphogenesis • positive regulation of ERK1 and ERK2 cascade • monocyte aggregation • positive regulation of monocyte aggregation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 960 12505 Ensembl ENSG00000026508 ENSMUSG00000005087 UniProt P16070 P15379 RefSeq (mRNA) NM_000610.3 NM_001039150.1 RefSeq (protein) NP_000601.3 NP_001034239.1 Location (UCSC) Chr 11:
35.16 – 35.25 Mb Chr 2:
102.81 – 102.9 Mb PubMed search

The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11.