Ccr2

CCR2

Identifiers Symbols CCR2; CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R External IDs OMIM: 601267 MGI: 106185 HomoloGene: 537 IUPHAR: CCR2 GeneCards: CCR2 Gene

Gene Ontology
Molecular function	• chemokine receptor activity • C-C chemokine receptor activity • CCR2 chemokine receptor binding • protein homodimerization activity
Cellular component	• cytoplasm • cytosol • plasma membrane • integral to plasma membrane • integral to membrane • dendrite • neuronal cell body • perikaryon • perinuclear region of cytoplasm
Biological process	• blood vessel remodeling • dendritic cell chemotaxis • positive regulation of T-helper 1 type immune response • negative regulation of type 2 immune response • cellular calcium ion homeostasis • chemotaxis • inflammatory response • immune response • cellular defense response • negative regulation of adenylate cyclase activity • elevation of cytosolic calcium ion concentration • JAK-STAT cascade • response to wounding • regulation of vascular endothelial growth factor production • positive regulation of T cell chemotaxis • negative regulation of angiogenesis • virus-host interaction • cytokine-mediated signaling pathway • cellular homeostasis • positive regulation of interferon-gamma production • positive regulation of interleukin-2 production • T-helper 17 cell chemotaxis • positive regulation of tumor necrosis factor biosynthetic process • negative regulation of eosinophil degranulation • innate immune response • positive regulation of alpha-beta T cell proliferation • positive regulation of inflammatory response • positive regulation of T cell activation • chemokine-mediated signaling pathway • positive regulation of monocyte chemotaxis • positive regulation of immune complex clearance by monocytes and macrophages • positive regulation of monocyte extravasation • positive regulation of CD8-positive, alpha-beta T cell extravasation • positive regulation of astrocyte chemotaxis • positive regulation of hematopoietic stem cell migration
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 729230 12772 Ensembl ENSG00000121807 ENSMUSG00000049103 UniProt P41597 P51683 RefSeq (mRNA) NM_001123041 NM_009915 RefSeq (protein) NP_001116513 NP_034045 Location (UCSC) Chr 3:
46.4 – 46.4 Mb Chr 9:
124.1 – 124.11 Mb PubMed search

C-C chemokine receptor type 2 (CCR2 or CD192 (cluster of differentiation 192) is a protein that in humans is encoded by the CCR2 gene. CCR2 is a chemokine receptor.