Carbazochrome - Mechanism of Action

Mechanism of Action

Carbazochrome, the semicarbazone of adrenochrome, that interacts with α-adrenoreceptors on surface of platelets, which are coupled to Gq protein and initiate PLC IP3/DAG pathway to increase intracellular free calcium concentration with these subsequent actions:

  • Activates PLA2 and induce arachidonic acid pathway to synthese endoperoxides (TxA2, thromboxane A2)
  • Calcium binds to calmodulin which then binds and activates myosin light-chain kinase, that will enable the myosin crossbridge to bind to the actin filament and allow contraction to begin. This will change platelet’s shape and induce release of serotonin, ADP, vWF (Von Willebrand factor), PAF (Platelet-activating factor) to promote further aggregation and adhesion.

Read more about this topic:  Carbazochrome

Famous quotes containing the words mechanism of, mechanism and/or action:

    Life is an offensive, directed against the repetitious mechanism of the Universe.
    Alfred North Whitehead (1861–1947)

    When one of us dies of cancer, loses her mind, or commits suicide, we must not blame her for her inability to survive an ongoing political mechanism bent on the destruction of that human being. Sanity remains defined simply by the ability to cope with insane conditions.
    Ana Castillo (b. 1953)

    The bugle-call to arms again sounded in my war-trained ear, the bayonets gleamed, the sabres clashed, and the Prussian helmets and the eagles of France stood face to face on the borders of the Rhine.... I remembered our own armies, my own war-stricken country and its dead, its widows and orphans, and it nerved me to action for which the physical strength had long ceased to exist, and on the borrowed force of love and memory, I strove with might and main.
    Clara Barton (1821–1912)