Extended Family
The Human Genome Project has revealed that there are more than a dozen other calpain isoforms, some with multiple splice variants. As the first calpain whose three-dimensional structure was determined, m-calpain is the type-protease for the C2 (calpain) family in the MEROPS database.
| Gene | Protein | Aliases | Tissue expression | Disease linkage |
|---|---|---|---|---|
| CAPN1 | Calpain 1 | Calpain-1 large subunit, Calpain mu-type | Central Nervous System | |
| CAPN2 | Calpain 2 | Calpain-2 large subunit | Central Nervous System | |
| CAPN3 | Calpain 3 | skeletal muscle retina and lens specific | Limb Girdle muscular dystrophy 2A | |
| CAPN5 | Calpain 5 | ubiquitous (high in colon, small intestine and testis) | might be linked to necrosis, as it is an ortholog of the C. elegans necrosis gene tra-3 |
|
| CAPN6 | Calpain 6 | CAPNX, Calpamodulin | ||
| CAPN7 | Calpain 7 | palBH | ubiquitous | |
| CAPN8 | Calpain 8 | exclusive to stomach mucosa and the GI track | might be linked to colon polyp formation | |
| CAPN9 | Calpain 9 | exclusive to stomach mucosa and the GI track | might be linked to colon polyp formation | |
| CAPN10 | Calpain 10 | susceptibility gene for type II diabetes | ||
| CAPN11 | Calpain 11 | testis | ||
| CAPN12 | Calpain 12 | ubiquitous but high in hair follicle | ||
| CAPN13 | Calpain 13 | testis and lung | ||
| CAPN14 | Calpain 14 | ubiquitous | ||
| SOLH | Calpain 15 | Sol H (homolog of the drosophila gene sol) | ||
| CAPNS1 | Calpain small subunit 1 | Calpain 4 | ||
| CAPNS2 | Calpain small subunit 2 |
Read more about this topic: Calpain
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