Brian K. Kennedy - Publications

Publications

• 1. Lunyak, V.V. and Kennedy, B.K. 2011. Aging worms erase history. Cell Metabol. 14: 147-148.

• 2. Kruegel, U., Robison, B. Dange, T. Kahlert, G., Delaney, J.R., Kotireddy, S., Tsuchiya, M., Tsuchiyama, S., Murakami, C.J., Schleit, J., Sutphin, G. Carr, D., Tar, K., Dittmar, G., Kaeberlein, M., Kennedy, B.K. and Schmidt, M. 2011. Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. PLoS Genet. PMID 21931558.

• 3. Delaney J.R., Sutphin, G.L., Dulken, B., Sim, S., Kim, J.R., Robison, B., Schleit, J., Murakami, C.J., Carr, D., An, E.H., Choi, E., Chou, A., Fletcher, M., Jelic, M., Liu, B., Lockshon, D., Moller, R.M., Pak, D.N., Peng, Q., Peng, Z.J., Pham, K.M., Sage, M., Solanky, A., Steffen, K.K., Tsuchiya, M., Tsuchiyama, S., Johnson, S. Raabe, C., Suh, Y., Zhou, Z., Liu, X., Kennedy, B.K., and Kaeberlein, M. 2011. Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell PMID: 21902802.

• 4. Kennedy, B.K. and McCormick, M.A. 2011. Asymmetric segregation: the shape of things to come. Curr. Biol. 21: R149-R151. PMID: 21334292.

• 5. Sutphin, G.L., Olsen. B.A., Kennedy, B.K. and Kaeberlein, M. Book chapter- Genome-wide analysis of yeast aging, In Aging Research in Yeast, Eds. Breitenbach, M., Laun, P. and Jazwinski, S.M., In press.

• 6. Kaeberlein, M., Kennedy, B.K., Liu, X., Suh, Y. and Zhou, Z. 2011. Meeting report: Trinations aging symposium. Mech. Ageing Dev. 132: 348-352.

• 7. Chen, S.C., Frett, E., Marx, J., Bosnakovski. D., Reed, X., Kyba, M. and Kennedy, B.K. 2011. Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1. PLoS ONE 6:e19780.

• 8. Burtner, C.R., Murakami, C.J., Olsen, B., Kennedy, B.K. and Kaeberlein, M. 2011. A genomic analysis of chronological longevity. Cell Cycle 10:1385-1396.

• 9. Delaney, J.R., Murakami, C.J., Olsen, B., Kennedy B.K., and Kaeberlein, M. 2011. Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell Cycle 10: 156-165.

• 10. Kaeberlein, M. and Kennedy, B.K. 2011. Hot topics in aging research: protein translation and TOR signaling, 2010. Aging Cell 10, 185-190.

• 11. McCormick, M.A. and Kennedy, B.K. 2010. Old yeast can’t handle the noise. Cell Metab. 39: 659-661.

• 12. Garelick, M.G. and Kennedy, B.K. 2010. TOR on the brain. Exp. Gerontol. 46: 153-163.

• 13. McCormick, M.A., Tsai, S.-Y. and Kennedy, B.K. 2010. TOR and aging: a complex pathway for a complex process. Phil. Trans. R. Soc. B 366: 17-27.

• 14. Oh, Y.S., Kim, D.G., Kim, G., Choi, E.-C., Kennedy, B.K., Suh, Y., Park, B.J. and Kim, S. 2010. Tumor suppessor AIMP3/p18 transgenic mice display a progeroid phenotype. Aging Cell 9: 810-822.

• 15. Burtner, C.R. and Kennedy, B.K. 2010. Progeria syndromes and ageing: What is the connection? Nat. Rev. Mol. Cell Biol. 11: 567-578.

• 16. Hale, J.S., Frock, R.L., Mamman, S.A., Fink, P.J., and Kennedy, B.K. 2010. Cell-extrinsic defective lymphocyte development in Lmna-/- mice. PLoS ONE 5:e10127.

• 17. Kennedy, B.K. and MacKay, V.L. 2009. Translate this…during dietary restriction. Cell Metab. 10: 247-248.

• 18. Schmidlin, T., Kennedy, B.K. and Daggett, V. 2009. Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V. Biophys. J. 97: 1709-1718.

• 19. Sutphin, G.L. and Kennedy, B.K. 2009. Aging: evolutionary theory meets genomic approaches. In P. Pontarotti (Ed.) Evolutionary biology: Concept, modeling and application. pp. 339-360.

• 20. Kennedy, B.K. and Kaeberlein, M. 2009. Hot topics in aging research: protein translation 2009. Aging Cell. 8: 617-623.

• 21. Steffen, K.K., Kennedy, B.K. and Kaeberlein, M. 2009. Measuring replicative life span in the budding yeast. J. Vis. Exp. pii: 1209. doi: 10.3791/1209.

• 22. Enns, L.C., Morton, J.F., Mangalindan, R.S., McKnight, G.S., Schwartz, M.W., Kaeberlein, M.R., Kennedy, B.K., Rabinovitch, P.S. and Ladiges, W.C. 2009. Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the C subunit of protein kinase A. J. Gerontol. A Biol. Sci. 64:1221-1321

• 23. Dang, W., Steffen, K.K., Perry, R., Dorsey, J. Johnson, F.B., Shilatifard, A., Kaeberlein, M. Kennedy, B.K., and Berger, S.L. 2009. Histone H4 lysine-16 acetylation regulates cellular lifespan. Nature 459, 802-807.

• 24. Stanfel, M.N., Shamieh, L.S., Kaeberlein, M., and Kennedy, B.K. 2009. The TOR pathway comes of age. Biochim. Biophys Acta 1790: 1067-1074.

• 25. Burtner, C.R., Murakami, C.J., Kennedy, B.K., and Kaeberlein, M. 2009. A molecular mechanism of chronological aging in yeast. Cell Cycle 8, 1256-1270.

• 26. Lee, D.C., Welton, K.L., Smith, E.D., and Kennedy B.K. 2009. A-type nuclear lamins act as transcriptional repressors when targeted to promoters. Exp. Cell Res. 315: 996-1007.

• 27. Kudlow, B.A., Stanfel, M.N., Burtner, C.R., Johnston, E.D., and Kennedy, B.K. 2008. Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53. Mol. Biol. Cell 19: 5238-5248.

• 28. Managbanag, J.R., Witten, T.M., Bonchev, D., Fox, L.A., Tsuchiya, M., Kennedy, B.K., and Kaeberlein, M. Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. PLoS One. 3: e3802.

• 29. Steinkraus, K.A., Kaeberlein, M. Kennedy, B.K. 2008. Replicative aging in yeast: the means to the end. Ann. Rev. Cell Dev. Biol. 24: 29-54.

• 30. Kaeberlein, M. and Kennedy, B.K. 2008 Hot topics protein translation 2008. Aging Cell 7: 777-782.

• 31. Steinkraus, K.A., Smith, E.D., Davis, C., Carr, D., Pendergrass, W.R., Supthin, G.L., Kennedy, B.K. and Kaeberlein, M. 2008. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell 7: 394-404.

• 32. Smith, E.D., Kaeberlein, T.L., Lydum, B.T., Sager, J., Welton, K.L., Kennedy, B.K., and Kaeberlein, M. 2008. Age- and calorie-independent life span extension from food restriction in Caenorhabditis elegans. BMC Dev. Biol. 8: 49.

• 33. Smith, E.D., Tsuchiya, M., Fox, L.A., Dang, N., Hu, D., Kerr, E.O., Johnston, E.D., Tchao, B.N., Pak, D.N., Welton, K.L., Promislow, D.E.L., Thomas, J.H., Kaeberlein, M. and Kennedy B.K. 2008. Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res. 18: 564-570.

• 34. Steffen, K.K., MacKay, V.L., Kerr, E.O., Tsuchiya, M., Hu, D., Fox, L.A., Dang, N., Johnston, E.D., Oakes, J.A., Tchao, B.N., Pak, D.N., Fields, S., Kennedy, B.K. and Kaeberlein, M. 2008. Yeast lifespan extension by depletion of 60S ribosomal subunits is mediated by Gcn4. Cell 133: 292-302.

• 35. Murakami, C.J., Burtner, C.R., Kennedy, B.K. and Kaeberlein, M. 2008. A method for high-throughput quantitative analysis of yeast chronological life span. J. Gerontol. A Biol. Sci. 63:113-121.

• 36. Kennedy, B.K. 2008. The genetics of aging: insight from genome-wide approaches in invertebrate model organisms. J. Int. Med. 263: 142-152.

• 37. Kaeberlein, M. Burtner, C.R. and Kennedy B.K. 2007. Recent developments in yeast aging. PLoS Genet. 3: 655-660.

• 38. Kennedy, B.K., Steffen, K.K. and Kaeberlein, M. 2007. Ruminations on dietary restriction and aging. Cell. Mol. Life Sci. 64: 1323-1328.

• 39. Nitta, R., Smith, C.L. and Kennedy, B.K. 2007. Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2. PLoS ONE. 2: e963.

• 40. Kaeberlein, M. and Kennedy, B.K. 2007. Protein translation, 2007. Aging Cell 6: 731-734.

• 41. Schmidlin, T., Kaeberlein, M. Kudlow, B.A., MacKay, V., Lockshon, D. and Kennedy, B.K. 2007. Single-gene deletions that restore mating competence to diploid yeast. FEMS Yeast Res. PMID: 17995956

• 42. Kaeberlein, M. and Kennedy, B.K. 2007. Does resveratrol activate yeast Sir2 in vivo? Aging Cell. 6: 415-416.

• 43. Kudlow, B.A., Kennedy, B.K. and Monnat, R.J. Jr. 2007. Werner syndrome and Hutchinson-Gilford progeria: mechanistic basis of human progeroid syndromes. Nat. Rev. Mol. Cell Biol. 8: 394-404.

• 44. Lockshon, D., Surface, L.E., Kerr, E.O., Kaeberlein, M., and Kennedy, B.K. 2007. The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics 175: 77-91.

• 45. Smith, E.D., Kennedy, B.K., and Kaeberlein, M. 2007. Genome-wide identification of conserved longevity genes in yeast and worms. Mech. Ageing Dev. 126: 106-111.

• 46. Tsuchiya, M., Dang, N., Kerr, E.O., Hu, D., Steffen, K.K., Oakes, J.A., Kennedy, B.K., and Kaeberlein, M. 2006. Sirtuin-independent effects of nicotinamide on life span extension from calorie restriction. Aging Cell 5:505-514.

• 47. Longo, V.D. and Kennedy, B.K. Sirtuins in aging and age-related disease. 2006. Cell 126:257-268.

• 48. Kaeberlein, T.L., Smith, E.D., Tsuchiya, M., Welton, K.L., Thomas, J.H., Fields, S., Kennedy, B.K., and Kaeberlein, M. 2006. Life span extension in Caenorhabditis elegans by complete removal of food. Aging Cell 5:487-494.

• 49. Kudlow, B.A. and Kennedy, B.K. 2006. Progeria and Aging: Are they connected by A-type lamins? Curr. Biol. 16: R652-654.

• 50. Kaeberlein, M., Steffen, K.K., Hu, D., Dang, N., Kerr, E.O., Tsuchiya, M., Fields, S., and Kennedy, B.K. 2006. Comment on “HST2 mediates SIR2-independent life-span extension by calorie restriction”. Science 312: 1312.

• 51. Nitta, R.T., Jameson, S.A., Kudlow, B.A., Conlan, L.A. and Kennedy, B.K. 2006. Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest. Mol. Cell. Biol. 26: 5360-5372.

• 52. Xu, Y., Leung, C.G., Lee, D.C., Kennedy, B.K. and Crispino, J.D. MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation. Leukemia, 20: 1261-1269.

• 53. Frock, R.L., Kudlow, B.A., Evans, A.M., Jameson, S.A., Hauschka, S.D. and Kennedy, B.K. 2006. Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev. 20: 486-500.

• 54. Powers, R.W. III, Kaeberlein, M., Caldwell, S.D., Kennedy, B.K., and Fields, S. 2006. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 20: 174-184.

• 55. Kennedy, B.K., Smith, E.D., and Kaeberlein, M. 2005. The enigmatic role of Sir2 in aging. Cell 123: 548-550.

• 56. Kaeberlein, M., Hu, D., Kerr, E.O., Tsuchiya, M., Westman, E.A., Dang, N., Fields, S., and Kennedy, B.K. 2005. Increased life span due to calorie restriction in respiratory deficient yeast. PLoS Genet. 1: 614-621.

• 57. Kaeberlein, M., Powers, R.W. III, Steffen, K.K., Westman, E.A., Hu, D., Dang, N., Kerr, E.O., Kirkland, K.T., Fields, S., and Kennedy, B.K. 2005. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310: 1193-1196.

• 58. Kudlow, B.A., Jameson, S.A., and Kennedy, B.K. HIV protease inhibitors block adipocyte differentiation independently of lamin A/C. AIDS 19: 1565-1573.

• 59. Barbie, D.A., Conlan, L.A., and Kennedy, B.K. 2005. Nuclear tumor suppressors in space and time. Trends Cell Biol. 15: 378-385.

• 60. Kaeberlein, M., Kirkland, K.T., Fields, S., and Kennedy, B.K. 2005. Genes determining yeast replicative life span in a long-lived genetic background. Mech. Ageing Dev. 126: 491-504.

• 61. Huang, S., Kennedy B.K., and Oshima, J. 2005. LMNA mutations in progeroid syndromes. Novartis Found. Symp. 264:197-202.

• 62. Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman E.A., Caldwell, S., Napper, A., Curtis, R., DiStefano, P.S., Fields, S. Bedalov, A. and Kennedy, B.K. 2005. Substrate specific activation of sirtuins by resveratrol.J. Biol. Chem. 280:17039-17045.

• 63. Smith E.D., Kudlow, B.A., Frock, R.L. and Kennedy, B.K. 2005. A-type nuclear lamins, progerias and other degenerative disorders. Mech. Ageing Dev. 126: 447-460.

• 64. Kaeberlein, M. and Kennedy, B.K. 2005. Large-scale identification in yeast of conserved ageing genes. Mech. Ageing Dev. 126: 17-21.

• 65. Kaeberlein, M., Kirkland, K.T., Fields, S., and Kennedy, B.K. 2004. Sir2-independent life span extension by calorie restriction in yeast. PLoS Biology 2: 1381-1387.

• 66. Johnson, B.R., Nitta, R., Frock, R.L., Mounkes, L., Barbie, D.A., Stewart, C., Harlow, E., and Kennedy, B.K. 2004. A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proc. Natl. Acad. Sci., USA 101: 9677-9682.

• 67. Barbie, D.A., Kudlow, B.A., Frock, R., Zhao, J., Johnson, B.R., Dyson, N., Harlow, E. and Kennedy, B.K. 2004. Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit. Mol. Cell. Biol. 24: 595-607.

• 68. Chen, L., Lee, L., Kudlow, B.A., Dos Santos, H.G., Sletvold, O., Shafeghati, Y., Botha, E.G., Garg, A., Hanson, N.B., Martin, G.M., Mian, I.S., Kennedy, B.K., and Oshima, J. 2003. LMNA mutations in atypical Werner’s syndrome. Lancet 362: 440-445.

• 69. Kennedy, B.K. 2002. Mammalian transcription factors in yeast: strangers in a familiar land. Nat. Rev. Mol. Cell Biol. 3: 41-49.

• 70. Kennedy, B.K., Liu, O.W., Dick, F.A., Dyson, N., Harlow, E. and Vidal, M. 2001. Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft. Proc. Natl. Acad. Sci., USA 98: 8720-5.

• 71. Lai, A., Kennedy B.K., Barbie, D.A., Berto, N.R., Yang, X.J., Theberge, M.-C., Seto, E., Zhang, Y., Reinberg, D., Harlow, E., and Branton, P.E. 2001. Retinoblastoma tumor suppressor family proteins repress transcription by recruiting the mSIN3 histone deacetylase complex via RBP1. Mol. Cell. Biol. 21: 2918-32.

• 72. Stevenson, L.F., Kennedy, B.K., and Harlow, E. 2001. A large-scale overexpression screen in S. cerevisiae identifies previously uncharacterized cell cycle genes. Proc. Natl. Acad. Sci., USA. 98: 3946-51.

• 73. Kennedy, B. K., Barbie, D.A., Classon, M., Dyson, N., and Harlow, E. 2000. Nuclear organization of DNA replication in primary mammalian cells. Genes Dev. 14: 2855-68.

• 74. Classon, M., Kennedy, B.K., Mulloy, R., and Harlow, E. 2000. Opposing roles of pRB and p107 in adipocyte differentiation. Proc. Natl. Acad. Sci., USA 97: 10826-10831.

• 75. Zhao, J., Kennedy, B.K., Lawrence, B.D., Barbie, D.A., Matera, A.G., Fletcher, J.A., and Harlow, E. 2000. NPAT links cyclin E-cdk2 to the regulation of replication-dependent histone gene transcription. Genes Dev. 14: 2283-2297.

• 76. Hannan, K.M., Kennedy, B.K., Cavanaugh, A.H., Hannan, R.D., Hirschler-Laszkiewicz, I., Jefferson, L.S., and Rothblum, L.I. 2000. RNA polymerase I transcription in confluent cells. Rb downregulates rDNA transcription during confluence induced cell cycle arrest. Oncogene 19: 3487-3497.

• 77. Kennedy, B.K., Gotta, M., Sinclair, D.A., Mills, K., McNabb, D.S., Murthy, M., Pak, S.M., Laroche, T., Gasser, S.M., and L. Guarente. 1997. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89: 381-391.

• 78. Gotta, M., Strahl-Bolsinger, S., Renauld, H., Laroche T., Kennedy, B.K., Grunstein, M., and S.M. Gasser. 1997. Localization of Sir2p: the nucleolus as a compartment for silent information regulators. EMBO J. 16: 3243-3255.

• 79. Kennedy, B.K. and L. Guarente. 1996. Genetic analysis of aging in Saccharomyces cerevisiae. Trends Genet. 12: 355-359.

• 80. Smeal, T., Claus, J., Kennedy, B., Cole, F., and L. Guarente. 1996. Loss of transcriptional silencing causes sterility in old mother cells of Saccharomyces cerevisiae. Cell 84: 633-642.

• 81. Prendergast, J.A., Singer, R.A., Rowley, N., Rowley, A., Johnston, G.C., Danos, M, Kennedy, B. and R.F. Gaber. 1995. Mutations sensitizing yeast cells to the start inhibitor nalidixic acid. Yeast 11: 537-547.

• 82. Kennedy, B.K., Austriaco, N.R. Jr., Zhang, J., and L. Guarente. 1995. Mutation in the silencing gene SIR4 can delay aging in Saccharomyces cerevisiae. Cell 80: 485-496.

• 83. Kennedy, B.K., Austriaco, N.R.Jr., and L. Guarente. 1994. Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J. Cell. Biol. 137: 1985-1993.

• 84. Gaber, R.F., Copple, D.M., Kennedy, B.K., Vidal, M., and M. Bard. 1989. The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol. Mol. Cell. Biol. 9: 3447-3456.