Cast
- Tom Hanks – Kip Wilson/Buffy (when in drag)
- Peter Scolari – Henry Desmond/Hildegarde (when in drag)
- Wendie Jo Sperber- Amy Cassidy, co-worker and friend who knows their secret
- Holland Taylor – Ruth Dunbar, their boss
- Donna Dixon – Sonny Lumet, Kip's love interest and hotel resident
- Telma Hopkins – Isabelle Hammond, hotel resident (hotel manager in the second season)
- Lucille Benson – Lilly Sinclair, hotel manager (1980–1981)
Read more about this topic: Bosom Buddies
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