Bobadilla is a surname of Spanish origin said to stem from the Arabic-Islamic origins of Abou Abdillah. The name refers to:
- Aldo Bobadilla (b. 1976), Paraguayan professional football player
- Diego López Pacheco Cabrera y Bobadilla, marqués de Villena (1599–1653), Spanish nobleman; viceroy of New Spain 1640–42
- Emilio Bobadilla Cáceres (1907–1979), Paraguayan guitarist and musician
- Francisco de Bobadilla (b. unknown, d. 1502), Spanish colonial administrator
- Francisco Mendoza de Bobadilla (1508–1566), Spanish Roman Catholic cardinal
- Geronimo de Bobadilla (b. unknown, d. 1680), Spanish Baroque painter
- Inés de Bobadilla (b. unknown, d. 1543), wife of Hernando de Soto; governor of Cuba
- Nicholas Bobadilla (1511–1590), Spanish Roman Catholic priest; one of the first Jesuits
- Raúl Bobadilla (b. 1987), Argentine professional football player
- Bobadilla, Chile, a town in Chile's Maule Region
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