**Biochemical systems theory** is a mathematical modelling framework for biochemical systems, based on ordinary differential equations (ODE), in which biochemical processes are represented using **power-law** expansions in the variables of the system.

This framework, which became known as Biochemical Systems Theory, has been developed since the 1960s by Michael Savageau and others for the systems analysis of biochemical processes. According to Cornish-Bowden (2007) they "regarded this as a general theory of metabolic control, which includes both metabolic control analysis and flux-oriented theory as special cases".

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