Benedicto is both a given name and a surname. Notable people with the name include:
- Benedicto Caldarella (born 1939), Argentine motorcycle road racer
- Benedicto Godoy Véizaga, Bolivian footballer who played in the 1950 World Cup
- Benedicto Kiwanuka (1922-1972), first Prime Minister of Uganda
- Benedicto de Moraes Menezes (1906-?), Brazilian footballer
- Benedicto Magnum Membrere (born 1982), Filipino basketball player
- Benedicto Villablanca (born 1957), Chilean former professional boxer
- Joaquín Dicenta Benedicto (1862–1917), Spanish journalist, novelist, playwright and poet
- José E. Benedicto, Treasurer of Puerto Rico
- Lourdes Benedicto (born 1974), American actress