Ayotte may refer to:
- Ayotte v. Planned Parenthood of Northern New England, a 2006 case in the US Supreme Court on the subject of abortion
- Kelly Ayotte (born 1968), junior United States Senator of New Hampshire and member of the Republican Party
- Ayotte Drums, drum producer
- Leo Ayotte (1909-1976), artist
- Mark Ayotte (born 1964), referee